Angiotensin AT1 receptor antagonism and protection against cardiovascular end-organ damage
نویسندگان
چکیده
منابع مشابه
Angiotensin II receptor blockade and end-organ protection: pharmacological rationale and evidence.
BACKGROUND The renin-angiotensin system is a widely studied hormonal system that comprises substrate-enzyme interactions, the end result of which is the production of the active peptide angiotensin II. Because angiotensin II affects blood pressure control, sodium and water homeostasis, and cardiovascular function and structure, a great deal of research effort has been directed toward blocking t...
متن کاملGrowth factor receptor transactivation in mediating end organ damage by angiotensin II.
Angiotensin II (Ang II) and its major heterotrimeric G protein-coupled receptor (GPCR) AT1 have long been believed to mediate end organ damage associated with cardiovascular and metabolic diseases. In the past decade, efforts have been made to dissect intracellular signal transduction mechanisms by which Ang II exerts its pathophysiological effects on target cells and tissues. Recent accumulati...
متن کاملEnd Organ Protection
Blood pressure and body fluid volume are mostly regulated by the renin-angiotensin system (RAS). It is evident that overactive RAS play a central role in the development of hypertension (HTN) and end organ damage (EOD) associated with HTN. It also plays a key role in a number of pathophysiological mechanisms leading to major cardiovascular (CV) events, such as myocardial infarction (MI), stroke...
متن کاملAT1 receptor antagonism attenuates target organ effects of salt excess in SHRs without affecting pressure.
Our recent studies have demonstrated that salt excess in the spontaneously hypertensive rat (SHR) produces a modestly increased arterial pressure while promoting marked myocardial fibrosis and structural damage associated with altered coronary hemodynamics and ventricular function. The present study was designed to determine the efficacy of an angiotensin II type 1 (AT(1)) receptor blocker (ARB...
متن کاملAldosterone and end-organ damage.
PURPOSE OF REVIEW This review highlights recent clinical studies demonstrating the contribution of aldosterone to cardiovascular mortality, vascular dysfunction, and renal injury in the context of advances in our understanding of the molecular biology of aldosterone. RECENT FINDINGS Mineralocorticoid receptor antagonism reduces mortality in patients with congestive heart failure and following...
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ژورنال
عنوان ژورنال: Journal of Human Hypertension
سال: 1998
ISSN: 0950-9240,1476-5527
DOI: 10.1038/sj.jhh.1000634